A novel subunit vaccine based on Fiber1/2 knob domain provides full protection against fowl adenovirus serotype 4 and induces stronger immune responses than a Fiber2 subunit vaccine

ABSTRACT: Outbreaks of hepatitis-hydropericardium syndrome (HHS) caused by fowl adenovirus serotype 4 (FAdV-4) have resulted in huge economic losses to the poultry industry in China since 2015.However, commercially Wirewound available vaccines against the FAdV-4 infection remain scarce.In our study, subunit vaccine candidates derived from the bacte

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Structural connectomics of anxious arousal in early adolescence: Translating clinical and ethological findings

Etiological explanations of clinical anxiety can be advanced through understanding the neural mechanisms associated with anxiety in youth prior to the emergence of psychopathology.In this vein, the present study sought to investigate how trait anxiety is related to features of the structural connectome in early adolescence.40 adolescents (21 female

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